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September 2016

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Squamous cell carcinoma (SCC) in situ, also known as Bowen disease, is SCC confined to the epidermis and superficial adnexal epithelium, further characterised by full-thickness involvement of the epidermis by dysplastic squamous cells. The term "Bowen disease" was originally used specifically to describe SCC in-situ in sun-protected skin as a harbinger of internal malignancy, but the terms "Bowen disease" and "SCC in situ" are now used interchangeably to describe epidermal SCC in situ of both sun-dam-aged and sun-protected skin.

Basal cell carcinoma (BCC) is a carcinoma derived from basal cells of the interfollicular epidermis and/or hair follicle. BCCs exhibit morphological variability but they invariably contain islands or nests of peripherally paliaded basaloid cells with hyperchromatic nuclei and scant cytoplasm.

Seborrhoeic keratosis is a benign intraepidermal neoplasm that most commonly occurs in ageing skin.

Keratoacanthoma is a common, rapidly growing squamoproliferative tumour that may spontaneously regress. It is histologically indistinguishable from (and likely a variant of) well-differentiated cutaneous invasive squamous cell carcinoma, with distinct clinical behavior.

Junctional, compound, and dermal naevi are benign localized neoplastic proliferations of naevus cells (a type of melanocyte). Like all melanocytic naevi, these lesions are defined by the presence of nests of melanocytes.

Lichen planus—like keratosis is a benign squamoproliferative lesion showing chronic inflammation and interface changes (likely representing active regression).

Actinic keratosis (AK) is an intraepithelial neoplastic lesion that may progress into invasive squamous cell carcinoma (SCC) or may spontaneously regress.

Dermatofibroma (fibrous histiocytoma) is a common benign papular or nodular skin lesion composed of variable combinations of fibroblastic cells, macrophages, and coarse collagen.

Cutaneous squamous cell carcinoma (SCC) is a malignancy of epidermal keratinocytes that exhibits various degrees of differentiation that partially recapitulate the cytology of squamous cells of the epidermal stratum spinosum. The lesions can be in situ or invasive with the potential for metastasis.

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